Side Effects

We understand that side effects might be a concern when thinking about starting a new medicine

In 2 clinical trials, CAPLYTA was proven to help control symptoms of schizophrenia with demonstrated safety.

Side effects of CAPLYTA

In the studies, the most common side effects of CAPLYTA were:

  • Sleepiness (24% with CAPLYTA vs 10% with placebo)

  • Dry mouth (6% with CAPLYTA vs 2% with placebo)

CAPLYTA can cause sleepiness and trouble concentrating. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities.

In clinical trials, sleepiness was predominantly mild. Your healthcare provider may tell you what time of day or evening is best for you to take CAPLYTA. Follow your healthcare provider’s direction on when and how to take CAPLYTA.

Does blood glucose, cholesterol, or triglycerides go up on CAPLYTA?

In clinical trials, changes in blood glucose, cholesterol, and triglycerides in patients taking CAPLYTA were similar to those in patients taking a sugar pill.

What about weight change?

In a long-term study, patients on CAPLYTA for one year had an average weight loss of 7 pounds.

CAPLYTA, like other drugs used to treat schizophrenia, may cause problems with your metabolism, including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood, and weight gain. Your doctor should check your blood sugar, fat levels, and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Tell your doctor if you have symptoms of high blood sugar, which include feeling very thirsty, hungry, sick to your stomach, weak/tired, or needing to urinate more than usual.

Each drug has its own specific risk profile.

Do patients on CAPLYTA experience movement disorders?

In clinical trials, movement disorders were uncommon and similar to sugar pill.

  • 6.7% of patients taking CAPLYTA vs. 6.3% of patients taking a sugar pill

Like other schizophrenia medications, CAPLYTA may cause movements that you cannot control in your face, tongue, or other body parts. This can be a sign of tardive dyskinesia. Tardive dyskinesia is a movement disorder that may not go away, even if you stop taking CAPLYTA. Tardive dyskinesia may also start after you stop taking CAPLYTA.