Transcript

The road to answers: Brook's story with bipolar I depression

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Video begins with white background and text in the center of the screen, and the ITCI logo centered at the bottom of the screen.

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Hear Brook's Bipolar I Depression Story

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The on screen text fades off screen and new text fades in. The ITCI logo remains in place.

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The patient in this video is sharing her individual experience at time of interview. She has been compensated for her time. This resource is brought to you by Intra-Cellular Therapies.

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Screen cuts to a view of trees with sunlight streaming through the branches. It then cuts to Brook and her family walking forward, carrying fishing gear.

(Brook)

I love being a mom, and spending time with my husband and our four kids. We really enjoy going outdoors. We like to go fishing and just sit by the water.

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Camera cuts to Brook talking to the camera with on screen text in the bottom left.

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Brook

Patient Advocate with Bipolar I Depression

(Brook)

It means so much to me to have something the whole family loves to do together. I cherish these moments, and learning to truly be there.

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Camera cuts to Brook preparing food in the kitchen.

(Brook)

I've had depression symptoms for as long as I can remember, but after I had my daughter, my symptoms were getting to the point where I knew that I couldn't handle them by myself. My depression got so bad, to the point where I couldn't leave my house, and I quit driving. The feelings of worry and fear consumed me. I would go to work and come home and go straight to my room. It was debilitating.

I felt a lot of guilt not being as present as I used to be as a mom. I used to feel like I was a super mom. I was also making impulsive decisions and not thinking of the consequences. It was very scary and difficult because I felt like nobody knew what I was going through.

At one point, I told my husband, "I need help," and I went to the hospital and checked myself in. It was the first of several times I ended up in the hospital over the next few years.

I saw different doctors and tried the medications they prescribed, but I didn't find the improvement I needed. I felt very defeated and hopeless.

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Camera shows Brook walking with her family outdoors.

(Brook)

Years went by, then I saw a psychiatrist who told me I had bipolar I depression. I didn't believe it. I have a family member who has bipolar I, and my symptoms were so different than theirs.

After I got diagnosed the second time with bipolar I depression, I began to realize that there's so many different symptoms. At that point I was prescribed different medications, and I experienced side effects like extreme weight gain. I think the biggest misconception is that everyone with bipolar depression has the same symptoms.

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Camera shows Brook sitting and talking with her doctor in an office setting.

(Brook)

As my psychiatrist and I talked about how to manage my bipolar I, she told me about CAPLYTA (lumateperone). It's an FDA-approved prescription medication used to treat depressive episodes associated with bipolar I or bipolar II disorder in adults.

My husband, who's one of my biggest supporters, found the CAPLYTA savings card on their website, which was really helpful. What I liked about CAPLYTA is that it's proven to deliver significant relief from depressive symptoms for bipolar I or II disorder. The dosing is convenient. I take one pill, once a day, with or without food.

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High cholesterol and weight gain may occur, as can high blood sugar, which may be fatal. Monitoring is recommended.

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Brook talking to camera

(Brook)

I learned that in CAPLYTA clinical trials, weight gain and movement disorders were not common. I really liked hearing that.

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Brook traveling by car

(Brook)

My doctor and I went over the potential benefits and risks of treatment. She said that I may see some improvements as early as the first week, with additional relief over the course of six weeks. But everyone's experience is different, and...

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Keep watching to hear more of Brook's story

(Brook)

...individual results with CAPLYTA may vary. I was really hopeful that CAPLYTA could be a good fit for me.

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Brook and her family spending time together in nature.

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Call your doctor about new or serious side effects like sudden mood changes, behaviors, or suicidal thoughts right away. Antidepressants may increase these risks.

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Report fever, confusion, stiff muscles, which may be life-threatening, or uncontrolled muscle movements, which may be permanent.

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High cholesterol and weight gain may occur, as can high blood sugar, which may be fatal. Monitoring is recommended.

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Common side effects are sleepiness, dizziness, nausea, and dry mouth. These aren't all the side effects.

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Camera cuts to Brook talking to camera

(Brook)

When I started taking CAPLYTA, I noticed some relief in my bipolar depression within a few weeks.

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Camera cuts to Brook playing with her children in nature

(Brook)

Finding relief of my symptoms, to me, means spending more quality time with my family. Being able to know that I'm making memories is so important to me. As part of my treatment plan, I also see my psychiatrist regularly.

I'm really proud of myself for getting through my darkest days with bipolar I. There are, of course, still days where I feel down. On those days, I turn to my family for support, and we work through it together.

Living with bipolar depression is not easy. I also find that listening to stories of others helps remind me that I'm not alone in this. My advice is to speak up for yourself and others, be persistent, and find the support you need.

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Screen goes white. Previous on screen text disappears and Important Safety Information appears on screen. The CAPLYTA logo remains in the bottom right corner and the ITCI logo is in the top right corner. Important Safety Information begins scrolling as it's read on voiceover.

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[ITCI logo]

[CAPLYTA logo] FOR BIPOLAR I & II DEPRESSION

Important Safety Information

Medicines like CAPLYTA can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). CAPLYTA is not approved for treating people with dementia-related psychosis.

CAPLYTA and antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Patients and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when CAPLYTA or an antidepressant medicine is started or when the dose is changed. Report any change in these symptoms to your healthcare provider immediately.

Do not take CAPLYTA if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (e.g., rash, itching, hives, swelling of the tongue, lip, face, or throat).

CAPLYTA may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia‑related psychosis that can lead to death.
Neuroleptic malignant syndrome (NMS): high fever, confusion, changes in your breathing, heart rate, and blood pressure, stiff muscles, and increased sweating; these may be symptoms of a rare but potentially fatal condition. Contact your healthcare provider or go to the emergency room if you experience signs and symptoms of NMS.
Uncontrolled body movements (tardive dyskinesia, TD) in your face, tongue, or other body parts. TD may not go away, even if you stop taking CAPLYTA. It may also occur after you stop taking CAPLYTA.
Problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Your healthcare provider should check your blood sugar, fat levels and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Call your healthcare provider if you have any of the following symptoms of high blood sugar: feeling very thirsty, hungry, sick to your stomach, needing to urinate more than usual, weak/tired, or confused, or your breath smells fruity.
Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with CAPLYTA.
Decreased blood pressure (orthostatic hypotension). You may feel lightheaded, dizzy, or faint when you rise too quickly from a sitting or lying position.
Falls. CAPLYTA may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause broken bones or other injuries.
Seizures (convulsions).
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities.
Problems controlling your body temperature so that you feel too warm. Avoid getting overheated or dehydrated while taking CAPLYTA.
Difficulty swallowing that can cause food or liquid to get into the lungs.

The most common side effects of CAPLYTA include sleepiness, dizziness, nausea, and dry mouth.

These are not all the possible side effects of CAPLYTA. Tell your healthcare provider if you have or have had heart problems or a stroke, high or low blood pressure, diabetes, or high blood sugar, problems with cholesterol, have or have had seizures (convulsions), kidney or liver problems, or a low white blood cell count. CAPLYTA may cause fertility problems in females and males. You should notify your healthcare provider if you become pregnant or intend to become pregnant while taking CAPLYTA. CAPLYTA may cause abnormal involuntary movements and/or withdrawal symptoms in newborn babies exposed to CAPLYTA during the third trimester. Talk to your healthcare provider if you breastfeed or are planning to breastfeed as CAPLYTA passes into breast milk. Tell your healthcare provider about all the medicines you're taking. CAPLYTA may affect the way other medicines work, and other medicines may affect how CAPLYTA works, causing possible serious side effects. Do not start or stop any medicines while taking CAPLYTA without talking to your healthcare provider. You are encouraged to report negative side effects of prescription drugs. Contact Intra‑Cellular Therapies, Inc. at 1‑888‑611‑4824 or FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch.

CAPLYTA is available in 10.5 mg, 21 mg, and 42 mg capsules.

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Previous on screen text disappears and the screen becomes blue. The CAPLYTA logo is in the middle of the screen. There is legal language in the bottom left corner and the ITCI logo is in the bottom right corner.

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