Transcript

Breaking the stigma: Vickie's bipolar I depression journey with Dr. Roma

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Video begins with white background and text in the center of the screen, and the ITCI logo centered at the bottom of the screen.

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Hear Vickie's Story with Bipolar II Depression

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The on screen text fades off screen and new text fades in. The ITCI logo remains in place.

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Screen cuts to Vickie sipping her coffee as she looks out her window at a wintery scene.

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The patient and healthcare provider in this video are sharing their individual experiences. They have been compensated for their time. This promotional resource is brought to you by Intra‑Cellular Therapies.

(Vickie)

I was diagnosed with bipolar I depression in my early 20s. It took some time to understand and identify with my diagnosis because there was a stigma about the word “bipolar.” I didn’t want to believe that it pertained to me. But since then, I’ve come to accept it, and I’ve tried to learn as much as I can about it.

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Cut to Vickie, speaking to camera

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Vickie / Patient Advocate with Bipolar I Depression

(Vickie)

One of the things I've learned is that bipolar disorder can be a hereditary disease. My husband and I have adult twin sons, and one of them has been diagnosed with bipolar I depression just like me.

Because I have experience living with bipolar depression, I was able to recognize his symptoms early on. So, our son had a much easier time getting the right diagnosis. And because of what I've gone through, I've been able to be stronger for him.

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Cut to Vickie dressing for winter outing

(Vickie)

I've spent a lot of time and energy over the years trying to find the right treatment plan for my bipolar I depression. And I've had a lot of counseling. I've also tried several different prescription medications. Some have worked better for me than others.

Sometimes I'd experience side effects like weight gain. One day, I was talking with my psychiatrist, Dr. Roma, about it. She suggested a treatment option called CAPLYTA® (lumateperone).

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Cut to Dr. Roma, speaking to camera

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Rebecca Roma, M.D. / Psychiatrist

(Dr. Roma)

CAPLYTA is an FDA-approved prescription medication used to treat depressive episodes associated with bipolar I or bipolar II disorder in adults. I often prescribe CAPLYTA for my patients with bipolar depression (bipolar I or bipolar II). Many don't know this, but there are actually very few approved medications for bipolar II depression, and CAPLYTA is one of them. It not only has proven efficacy in reducing depressive symptoms from bipolar I and II, but it has a well-established safety profile and it's generally well-tolerated for most patients.

Also, I love how convenient the dosing schedule is. It's just one pill, once a day, and patients don't have to "titrate up" to reach the effective dose. I thought CAPLYTA would be an excellent choice for Vickie. Of course, every patient's experience with CAPLYTA will be different.

I do tell my patients who take CAPLYTA to call me immediately if they experience potential side effects such as sudden mood changes, behaviors, or suicidal thoughts and to come to me with any concerns or questions they may have about treatment.

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Vickie meets up with friends at craft workshop

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CAPLYTA can increase the risk of sudden mood changes, behaviors, or suicidal thoughts. Call your healthcare provider right away if you experience these symptoms.

(Dr. Roma)

I have them review the Important Safety Information for CAPLYTA, which is also included at the end of this video. And I should mention that CAPLYTA is not approved for dementia-related psychosis, as it can increase the risk of death or stroke.

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Vickie makes mosaic project with friends

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Please see Important Safety Information throughout and at the end of this video. CAPLYTA is not approved for dementia-related psychosis.

(Vickie)

Dr. Roma and I had a really good conversation about CAPLYTA. I was excited to hear about it! I learned that in CAPLYTA clinical trials, weight gain and movement disorders were not common which was important to me.

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High cholesterol and weight gain may occur, as can high blood sugar which may be fatal. Monitoring is recommended.

(Dr. Roma)

I tell my patients that CAPLYTA is proven to deliver meaningful symptom relief from both bipolar I and II depression. And that they may see some improvement in the first week with additional relief over the course of six weeks.

Again, everyone's experience is different. Like with any medication, there is a potential for side effects. I tell my patients to report fever, confusion, or stiff muscles, which may be life-threatening, or uncontrolled muscle movements, which may be permanent.

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Call your doctor if you experience fever, confusion, stiff muscles, or uncontrolled muscle movements.

(Vickie)

Before I started CAPLYTA, I told Dr. Roma about all the medical conditions I had and medications that I was taking. Dr. Roma and I went over the potential benefits and risks of treatment, including the most common side effects such as sleepiness, dizziness, nausea, and dry mouth.

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The most common side effects of CAPLYTA include sleepiness, dizziness, nausea, and dry mouth.

(Vickie)

So, I took one pill, once a day, right before bedtime. About 2-3 weeks after starting treatment with CAPLYTA, I felt some improvement in my bipolar depression symptoms and I was so encouraged by that!

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Vickie makes banana bread while talking to friends

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Individual results may vary. Talk to your doctor to see if CAPLYTA might be right for you.

(Dr. Roma)

I have been happy with the progress Vickie has made on CAPLYTA. She and I have a good working relationship. I'm also in close contact with her therapist. Vickie is always open and proactive when it comes to managing her bipolar I depression. That's what's helped us get to the treatment plan she's on now.

(Vickie)

Since taking CAPLYTA along with regular counseling, I feel like I'm more in control of my bipolar depression instead of it controlling me.

I'm pursuing things that I'm passionate about. I'm speaking out about bipolar disorder more than ever. I'm becoming more of an advocate not only for myself, but also for our adult son.

Even though he lives 500 miles away, I want him to see that bipolar I depression is a condition that he can live with and manage and still thrive. I want to be a good example for him. To me, that makes everything that I've gone through worth it.

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Screen goes white. Important Safety Information appears on screen. The CAPLYTA logo remains in the bottom right corner and the ITCI logo is in the top right corner. Important Safety Information begins scrolling as it's read on voiceover.

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Important Safety Information

Medicines like CAPLYTA can raise the risk of death in elderly people who have lost touch with reality (psychosis), due to confusion and memory loss (dementia). CAPLYTA is not approved for treating people with dementia-related psychosis.

CAPLYTA and antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults, especially within the first few months of treatment or when the dose is changed. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Patients and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when CAPLYTA or an antidepressant medicine is started, or when the dose is changed. Report any change in these symptoms to your healthcare provider immediately.

Do not take CAPLYTA if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (e.g., rash, itching, hives, swelling of the tongue, lip, face, or throat).

CAPLYTA may cause serious side effects, including:

Stroke (cerebrovascular problems) in elderly people with dementia‑related psychosis that can lead to death.
Neuroleptic malignant syndrome (NMS): high fever, confusion, changes in your breathing, heart rate, and blood pressure, stiff muscles, and increased sweating; these may be symptoms of a rare but potentially fatal condition. Contact your healthcare provider or go to the emergency room if you experience signs and symptoms of NMS.
Uncontrolled body movements (tardive dyskinesia, TD) in your face, tongue, or other body parts. TD may not go away, even if you stop taking CAPLYTA. It may also occur after you stop taking CAPLYTA.
Problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Your healthcare provider should check your blood sugar, fat levels and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Call your healthcare provider if you have any of the following symptoms of high blood sugar: feeling very thirsty, hungry, sick to your stomach, needing to urinate more than usual, weak/tired, or confused, or your breath smells fruity.
Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with CAPLYTA.
Decreased blood pressure (orthostatic hypotension). You may feel lightheaded, dizzy, or faint when you rise too quickly from a sitting or lying position.
Falls. CAPLYTA may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause broken bones or other injuries.
Seizures (convulsions).
Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities.
Problems controlling your body temperature so that you feel too warm. Avoid getting overheated or dehydrated while taking CAPLYTA.
Difficulty swallowing that can cause food or liquid to get into the lungs.

The most common side effects of CAPLYTA include sleepiness, dizziness, nausea, and dry mouth.

These are not all the possible side effects of CAPLYTA. Tell your healthcare provider if you have or have had heart problems or a stroke, high or low blood pressure, diabetes, or high blood sugar, problems with cholesterol, have or have had seizures (convulsions), kidney or liver problems, or a low white blood cell count. CAPLYTA may cause fertility problems in females and males. You should notify your healthcare provider if you become pregnant or intend to become pregnant while taking CAPLYTA. CAPLYTA may cause abnormal involuntary movements and/or withdrawal symptoms in newborn babies exposed to CAPLYTA during the third trimester. Talk to your healthcare provider if you breastfeed or are planning to breastfeed as CAPLYTA passes into breast milk. Tell your healthcare provider about all the medicines you're taking. CAPLYTA may affect the way other medicines work, and other medicines may affect how CAPLYTA works, causing possible serious side effects. Do not start or stop any medicines while taking CAPLYTA without talking to your healthcare provider. You are encouraged to report negative side effects of prescription drugs. Contact Intra‑Cellular Therapies, Inc. at 1‑888‑611‑4824 or FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch.

CAPLYTA is available in 10.5 mg, 21 mg, and 42 mg capsules.

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Previous on screen text disappears and the screen becomes blue. The CAPLYTA logo is in the middle of the screen. There is legal language in the bottom left corner and the ITCI logo is in the bottom right corner.

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